Mireille Broeders first got involved with cancer screening during her PhD project (Radboud University, 2004) where she evaluated the impact of the Nijmegen breast screening program, established already in the mid-70s of the last era. Over the past decade, she has developed a research line to identify the added value of introducing personalized risk-based approaches in the current age-based cancer screening programs, with a focus on breast cancer screening. As Professor of Personalized Cancer Screening, prof. Broeders initiated the nation-wide PRISMA study and created a unique screening cohort where all information to assess a woman’s individual risk for breast cancer has been collected prospectively from 50,000 women. Through her position at the Dutch Expert Centre for Screening (LRCB), prof. Broeders further performs research to improve the quality of breast cancer screening. With her team and collaborators, she explores the possibilities of introducing technological developments, particularly AI algorithms. In the near future, prof. Broeders aims to apply insights gained in breast cancer screening to other established and potential new cancer screening programs.